Benzenesulfonic acids and derivatives
eMolecules 80-48-8 | Methyl p-toluenesulfonate | Combi-Blocks | MFCD00008417 | 186.230 | C8H10O3S | 95.000 | COS(=O)(=O)c1ccc(C)cc1 | 25g | 415498342
Methyl p-toluenesulfonate | Combi-Blocks | 80-48-8 | MFCD00008417 | 186.230 | C8H10O3S | 95.000 | COS(=O)(=O)c1ccc(C)cc1 | 25g | 415498342
eMolecules 80-48-8 | Methyl 4-toluenesulfonate | Oakwood Chemicals | MFCD00008417 | 186.230 | C8H10O3S | 98.000 | COS(=O)(=O)c1ccc(C)cc1 | 5g | 480156143
Methyl 4-toluenesulfonate | Oakwood Chemicals | 80-48-8 | MFCD00008417 | 186.230 | C8H10O3S | 98.000 | COS(=O)(=O)c1ccc(C)cc1 | 5g | 480156143
Medchemexpress LLC P-toluenesulfonic acid-d7 monohydrate | 1219795-22-8 | 99.8% | 197.26 g/mol | C7H3D7O4S | 25 MG
p-Toluenesulfonic acid-d7 monohydrate is the deuterium-labeled monohydrate of p-toluenesulfonic acid. It functions as a strong organic acid and is used both as an acid catalyst in synthetic chemistry and as an internal standard or tracer for quantitative NMR, GC-MS, and LC-MS analyses.
- Deuterium-labeled for use as an internal standard or tracer in NMR and mass spectrometry.
- High isotopic purity (99.76%) for accurate quantitative analysis.
- Solid form, easy to weigh and handle for small-scale analytical applications.
- Suitable as an acid catalyst in organic synthesis.
- Available in multiple small package sizes for analytical workflows.
Medchemexpress LLC P-toluenesulfonic acid-d7 monohydrate | 1219795-22-8 | 99.8% | 197.26 | C7H3D7O4S | 10 MG
p-Toluenesulfonic acid-d7 monohydrate is a deuterium-labeled analog of p-toluenesulfonic acid (monohydrate) used as a strong organic acid and catalyst in organic synthesis and analytical studies. The deuterium labeling supports mechanistic investigations and NMR tracing, and the material is supplied at high isotopic and chemical purity for research use.
- Deuterium-labeled for tracing and NMR studies.
- Monohydrate form for consistent handling and reproducibility.
- High purity (99.76%) suitable for analytical and research applications.
- Functions as a strong organic acid and catalyst in synthesis.
- Available in small pack sizes for laboratory and analytical work.
Medchemexpress LLC I-138 | 2098211-50-6 | C26H23F3N6O | 25 MG
I-138 is an orally active, reversible inhibitor of USP1-UAF1, with an IC50 of 4.1 nM and a Ki of 5.4 nM. It induces monoubiquitination of FANCD2 and PCNA in cells and eliminates USP1 autocleavage in cells. It is structurally related to ML323.
- Reversible inhibitor of USP1-UAF1
- Induces monoubiquitination of FANCD2 and PCNA in cells
- Eliminates USP1 autocleavage in cells
- Inhibits MDA-MB-436 cell viability
- Shows modest antitumor activity in mice bearing MDA-MB-436 tumors
- Can be combined with Niraparib for BRCA1/2 mutant tumor inhibition
Medchemexpress LLC 2-Ketoglutaric acid | 328-50-7 | 99.68% | 146.10 | 1MG
2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate involved in the production of ATP or GTP within the Krebs cycle. It also serves as the primary carbon skeleton for nitrogen-assimilatory reactions. Additionally, 2-Ketoglutaric acid functions as a reversible inhibitor of tyrosinase, with an IC50 of 15 mM.
- Reduction of ammonia levels formed in the lung and general ammonia detoxification.
- Protective role against lipid peroxidation.
- Neuroprotective effect against cyanide poisoning.
- Acts as a precursor for the synthesis of amino acids and nucleotides.
Selleck Chemical LLC 2-Ketoglutaric acid
2-Ketoglutaric acid (alpha-ketoglutarate) is a key molecule in the TCA cycle playing a fundamental role in determining the overall rate of this important metabolic process In the TCA cycle AKG is decarboxylated to succinyl-CoA and carbon dioxide by AKG dehydrogenase which functions as a key control point of the TCA cycle 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase
Cayman Chemical a-KetoglutarIc AcId 500g
An intermediate in the citric acid cycle; precursor of glutamine and glutamate and an antioxidant with roles in immune homeostasis, aging, protein synthesis, and bone development
eMolecules 80-48-8 | Methyl 4-toluenesulfonate | Oakwood Chemicals | MFCD00008417 | 186.230 | C8H10O3S | 98.000 | COS(=O)(=O)c1ccc(C)cc1 | 10g | 480156144
Methyl 4-toluenesulfonate | Oakwood Chemicals | 80-48-8 | MFCD00008417 | 186.230 | C8H10O3S | 98.000 | COS(=O)(=O)c1ccc(C)cc1 | 10g | 480156144
Medchemexpress LLC p-Toluenesulfonic acid monohydrate | 6192-52-5 | MFCD00142137 | 99.8% | 190.22 g·mol⁻¹ | C7H10O4S | 500 G
p-Toluenesulfonic acid monohydrate is a strong organic sulfonic acid supplied as the monohydrate salt. It is commonly used as an acid catalyst in organic synthesis and for research and analytical applications. The solid material offers high purity and is suitable for laboratory reactions, analytical standards, and catalytic transformations.
- Strong organic acid and catalyst for dehydration and esterification reactions.
- Supplied as a monohydrate solid for convenient handling and storage.
- High purity (≈99.8%) appropriate for research and analytical use.
- Suitable for use as an analytical standard and reagent in synthesis.
- Compatible with common polar organic solvents; readily soluble.
- Available in multiple pack sizes to support small- and large-scale work.
Medchemexpress LLC I-138 | 2098211-50-6 | C26H23F3N6O | 1 MG
I-138 is an orally active, reversible inhibitor of USP1-UAF1 (IC50: 4.1 nM; Ki: 5.4 nM), structurally related to ML323 (HY-17543). I-138 induces monoubiquitination of FANCD2 and PCNA in cells and eliminates USP1 autocleavage in cells.
- Orally active and reversible inhibitor of USP1-UAF1.
- Potent inhibitory activity against USP1-UAF1 (IC50: 4.1 nM; Ki: 5.4 nM).
- Induces monoubiquitination of FANCD2 and PCNA in cells.
- Eliminates USP1 autocleavage in cells.
- Demonstrates modest antitumor activity in mice bearing MDA-MB-436 tumors.
- Shows enhanced inhibition of BRCA1/2 mutant tumors in vivo when combined with the PARP inhibitor Niraparib.
Medchemexpress LLC I-138 | 2098211-50-6 | C26H23F3N6O | 50 MG
I-138 is an orally active, reversible inhibitor of USP1-UAF1 (IC50: 4.1 nM; Ki: 5.4 nM), structurally related to ML323. It induces monoubiquitination of FANCD2 and PCNA in cells and eliminates USP1 autocleavage in cells.
- Eliminates USP1 self-lysis in HAP-1 USP1 WT and knockout cells
- Induces monoubiquitination of FANCD2 and PCNA in MDA-MB-436 cells
- Dose-dependently inhibits MDA-MB-436 cell viability
- Results in USP1 inhibition and modest antitumor activity in mice bearing MDA-MB-436 tumors
- Benefits BRCA1/2 mutant tumor inhibition when combined with Niraparib